Herbal Medicine and Acupuncture

Biography

Biography: THIRI MYO KHAING,MD

Abstract

General objective of this research is to compare the whitening effect in facial skin between 3% Glycine max and  2% Alpha Arbutin in Thais. Research Hypothesis is 3% Glycine max extract cream has a better efficacy and satisfactory evaluation in facial skin whitening more than 2% Alpha Arbutin cream.The excepted benefits are 1)use glycine max as an alternative to whiten the facial skin and 2)to use as a database for future research.Alpha Arbutin is a standard cream for the facialwhitening with anti-tyrosinase activity.Glycine Max(soy bean) has skin lighting effect by acting as a melanosome transfer inhibitor.Male and Female 30 subjects, age between 20 and 60 years with Fitzpatrick Skin type III-VI were consulted by dermatologist and matched with all inclusion criteria were enrolled. 3% Glycine max extract cream and 2% Alpha Arbutin were applied randomly by using block randomization in a split face design (right and left sides). Both 3% Glycine max extract cream and 2% Alpha Arbutin have similar color, consistency and smell. Volunteers applied the creams two times per day for 8 weeks. Moreover, mild soaps and sunscreens were given to the volunteers. Skin whitening was evaluated at baseline, 4^th and 8^th weeks by measuring mean melanin index by mexameter® MX18 and comparing the photography VISIA® analysis. Satisfactory score and adverse effects of the volunteers were observed and evaluated by three dermatologists and will be recorded throughout the study. Research location is at Mae Fah Luang Hospital, Asoke, Bangkok.